姓名:

鄭竣亦 Shi-Yie Cheng

職稱:

副教授

學歷:

國立中山大學 海洋資源學系 學士
國立中山大學 海洋生物科技暨資源學系 碩士
國立中山大學 海洋生物科技暨資源學系 博士

經歷: 國立中山大學 亞太海洋中心(杜昌益教授實驗室) 博士後研究員
中國醫藥大學 生物多樣性研究中心(周昌弘院士實驗室) 博士後研究員
國立高雄大學 生命科學系 助理教授
辦公室:

理學院大樓 608 室

實驗室:

天然物化學實驗室(理學院大樓 505-1 室)

聯絡電話:

886-7-5916693,校內分機 7693

E-Mail:

shiyie@nuk.edu.tw

學術專長:

天然物結構鑑定
有機光譜學
天然物化學
有機化學

研究方向:

海洋無脊椎動物與陸地植物(中草藥)活性天然物研究(濃縮萃取純化、化合物結構鑑定、有效成分結構修飾、生合成推演、化合物結構和活性探討)與開發(保健產品)。

開授課程:

(大學部) 有機化學、分析化學、天然物化學、生物科技概論

研究計劃:

1.計畫名稱:台灣八角金盤活性天然物分離純化、結構鑑定、衍生物之製備及其植物相生相剋作用機制
計畫單位:國科會
執行期間:101/08/01 — 102/07/31
參與工作:共同主持人
計畫編號:NSC 101-2621-B-039-002

2.計畫名稱:軟珊瑚Nephthea erectaNephthea chabroli之活性二次代謝物研究
計畫單位:國科會
執行期間:102/08/01 — 103/07/31
參與工作:主持人
計畫編號:NSC 102-2113-M-390-001


3.計畫名稱:龍涎香與鱷嘴花的二次代謝物純化、結構鑑定、化學修飾及其生物活性研究
計畫單位:科技部
執行期間:103/08/01 — 104/07/31
參與工作:主持人
計畫編號:MOST 104-2320-B-390-001

4.計畫名稱:龍涎香與鱷嘴花的二次代謝物純化、結構鑑定、衍生物之製備及其生物活性研究
計畫單位:科技部
執行期間:104/08/01 — 105/07/31
參與工作:主持人
計畫編號:MOST 104-2320-B-390-001

5.計畫名稱:旋覆花活性代謝物與衍生物的抗發炎和降血糖作用與機制之研究
計畫單位:科技部
執行期間:105/08/01 — 106/07/31
參與工作:主持人

計畫編號:MOST 105-2320-B-390-001

期刊論文:

1. Khalil, A. T.; Shen, Y.-C.;* Guh, J.-H.; Cheng, S.-Y.
(2005) "Two new sesquiterpene lactones from Ixeris chinensis" Chem. Pharm. Bull. 53, 15-17. (SCI) [國科會計畫編號:NSC91-2320-B-110-009]

 

2. El-Gamal, A. A. H.; Chiu, E.-P.; Li, C.-H.; Cheng, S.-Y.; Dai, C.-F.; Duh, C.-Y.*
(2007) "Sesquiterpenoids and norsesquiterpenoids from the Formosan soft coral Lemnalia laevis" J. Nat. Prod. 68, 1749-1753. (SCI) [國科會計畫編號:NSC95-2320-B-110-003-MY3]

 

3. Shen, Y.-C.;* Cheng, S.-Y.; Kuo, Y.-H.; Hwang, T.-L.; Chiang, M. Y.; Khalil, A. T.
(2007) "Chemical transformation and biological activities of ambrein, a major product of ambergris from Physeter macrocephalus (sperm whale)" J. Nat. Prod. 70, 147-153. (SCI) [國科會計畫編號:NSC93-2811-B-110-004]

 

4. Cheng, S.-Y.; Dai, C.-F.; Duh, C.-Y.*
(2007) "New 4-methylated and 19-oxygenated steroids from the Formosan soft coral Nephthea erecta" Steroids 72,653-659. (SCI) [國科會計畫編號:NSC95-2320-B-110-003-MY3]

 

5. Cheng, S.-Y.; Dai, C.-F.; Duh, C.-Y.*
(2007) "Sesquiterpenoids and artificial 19-oxygenated steroids from the Formosan soft coral Nephthea erecta" J. Nat. Prod. 70, 1449-1453. (SCI) [國科會計畫編號:NSC95-2320-B-110-003-MY3]

 

6. Cheng, S.-Y.; Wen, Z.-H.; Chiou, S.-F.; Wang, S.-K.; Hsu, C.-H.; Dai, C.-F.; Chiang, M. Y.; Duh, C.-Y.*
(2008) "Durumolides A–E, anti-inflammatory and antibacterial cembranolides from the soft coral Lobophytum durum" Tetrahedron 64, 9698-9704. (SCI) [國科會計畫編號:NSC96-2320-B-110-003-MY3]

 

7. Cheng, S.-Y.; Wen, Z.-H.; Wang, S.-K.; Chiang, M. Y.; El-Gamal, A. A. H.; Dai, C.-F.; Duh, C.-Y.*
(2009) "Revision of the absolute configuration at C(23) of lanostanoids and isolation of secondary metabolites from the Formosan soft coral Nephthea erecta" Chem. Biodivers. 6, 86-95. (SCI) [國科會計畫編號:NSC96-2320-B-110-003-MY3]

 

8. Cheng, S.-Y.; Wen, Z.-H.; Wang, S.-K.; Chiou, S.-F.; Hsu, C.-H.; Dai, C.-F.; Chiang, M. Y.; Duh, C.-Y.*
(2009) "Unprecedented hemiketal cembranolides with anti-inflammatory activity from the soft coral Lobophytum durum" J. Nat. Prod. 72, 152-155. (SCI) [國科會計畫編號:NSC96-2320-B-110-003-MY3]

 

9. Cheng, S.-Y.; Huang, Y.-C.; Wen, Z.-H.; Chiou, S.-F.; Wang, S.-K.; Hsu, C.-H.; Dai, C.-F.; Duh, C.-Y.*
(2009) "Novel sesquiterpenes and norergosterol from the soft corals Nephthea erecta and Nephthea chabroli" Tetrahedron Lett. 50, 802-806. (SCI) [國科會計畫編號:NSC96-2320-B-110-003-MY3]

 

10. Cheng, S.-Y.; Huang, Y.-C.; Wen, Z.-H.; Hsu, C.-H.; Wang, S.-K.; Dai, C.-F.; Duh, C.-Y.*
(2009) "New 19-oxygenated and 4-methylated steroids from the Formosan soft coral Nephthea chabroli" Steroids 74, 543-547. (SCI) [國科會計畫編號:NSC96-2320-B-110-003-MY3]

 

11. Cheng, S.-Y.; Wen, Z.-H.; Chiou, S.-F.; Tsai, C.-W.; Wang, S.-K.; Hsu, C.-H.; Dai, C.-F.; Chiang, M. Y.; Wang, W.-H.; Duh, C.-Y.*
(2009) "Ceramide and cerebrosides from the octocoral Sarcophyton ehrenbergi" J. Nat. Prod. 72, 465-468. (SCI) [國科會計畫編號:NSC96-2320-B-110-003-MY3]

 

12. Cheng, S.-Y.; Wen, Z.-H.; Chiou, S.-F.; Wang, S.-K.; Hsu, C.-H.; Dai, C.-F.; Duh, C.-Y.*
(2009) "Anti-inflammatory cembranolides from the soft coral Lobophytum durum" Bioorg. Med. Chem. 17, 3763-3769. (SCI) [國科會計畫編號:NSC96-2320-B-110-003-MY3]

 

13. Lin, S.-T.; Wang, S.-K.; Cheng, S.-Y.; Duh, C.-Y.*
(2009) "Lobocrasol, a new diterpenoid from the soft coral Lobophytum crassum" Org. Lett. 11, 3012-3014. (SCI) [國科會計畫編號NSC96-2320-B-110-003-MY3]

 

14. Cheng, S.-Y.; Huang, K.-J.; Wang, S.-K.; Wen, Z.-H.; Hsu, C.-H.; Dai, C.-F.; Duh, C.-Y.*
(2009) "New terpenoids from the soft corals Sinularia capillosa and Nephthea chabroli" Org. Lett. 21, 4830-4833. (SCI) [國科會計畫編號:NSC96-2320-B-110-003-MY3]

 

15. Cheng, S.-Y.; Wang, S.-K.; Wen, Z.-H.; Dai, C.-F.; Duh, C.-Y.*
(2009) "Three new eudesmanoids from the Formosan soft coral Nephthea erecta" J. Asian Nat. Prod. Res. 11, 967-973. (SCI) [國科會計畫編號:NSC96-2320-B-110-003-MY3]

 

16. Cheng, S.-Y.; Lin, E.-H.; Huang, J.-S.; Wen, Z.-H.; Duh, C.-Y.*
(2010) "Ylangene-type and nardosinane-type sesquiterpenoids from the soft corals Lemnalia flava and Paralemnalia thyrsoides" Chem. Pharm. Bull. 58, 381-385. (SCI) [國科會計畫編號:NSC96-2320-B-110- 003-MY3]

 

17. Cheng, S.-Y.; Wang, S.-K.; Chiou, S.-F.; Hsu, C.-H.; Dai, C.-F.; Chiang, M. Y.; Duh, C.-Y.*
(2010) "Cembranoids from the octocoral Sarcophyton ehrenbergi" J. Nat. Prod. 73, 197-203. (SCI) [國科會計畫編號:NSC96-2320-B-110-003-MY3]

 

18. Cheng, S.-Y.; Huang, K.-J.; Wang, S.-K.; Wen, Z.-H.; Chen, P.-W.; Duh, C.-Y.*
(2010) "Antiviral and anti-inflammatory metabolites from the soft coral Sinularia capillosa" J. Nat. Prod. 73, 771-775. (SCI) [國科會計畫編號:NSC96-2320-B-110-003-MY3]

 

19. Cheng, S.-Y.; Chuang, C.-T.; Wen, Z.-H.; Wang, S.-K.; Chiou, S.-F.; Hsu, C.-H.; Dai, C.-F.; Duh, C.-Y.*
(2010) "Bioactive norditerpenoids from the soft coral Sinularia gyrosa" Bioorg. Med. Chem. 18, 3379-3386. (SCI) [國科會計畫編號:NSC96-2320-B-110-003-MY3]

 

20. Cheng, S.-Y.; Lin, E.-H.; Wen, Z.-H.; Chiang, M. Y.; Duh, C.-Y.*
(2010) "Two new verticillane-type diterpenoids from the Formosan soft coral Cespitularia hypotentaculata" Chem. Pharm. Bull. 58, 848-851. (SCI) [國科會計畫編號:NSC96-2320-B-110-003-MY3]

 

21. Cheng, S.-Y.; Chuang, C.-T.; Wang, S.-K.; Wen, Z.-H.; Chiou, S.-F.; Hsu, C.-H.; Dai, C.-F.; Duh, C.-Y.*
(2010) "Antiviral and anti-inflammatory diterpenoids from the soft coral Sinularia gyrosa" J. Nat. Prod. 73, 1184-1187. (SCI) [國科會計畫編號:NSC96-2320-B-110-003-MY3]

 

22. Cheng, S.-Y.; Chen, H.-P.; Wang, S.-K.;* Duh, C.-Y.*
(2011) "Three new 9,11-secosterols from the Formosan soft coral Sinularia leptoclados" Bull. Chem. Soc. Jpn. 84, 648-652. (SCI) [國科會計畫編號:NSC99-2628-B-110-002-MY3]

 

23. Cheng, S.-Y.; Lin, S.-T.; Wang, S.-K.;* Duh, C.-Y.*
(2011) "α-Tocopherols from the Formosan soft coral Lobophytum crassum" Bull. Chem. Soc. Jpn. 84, 783-787. (SCI) [國科會計畫編號:NSC99-2628-B-110-002-MY3]

 

24. Cheng, S.-Y.; Chen, P.-W.; Chen, H.-P.; Wang, S.-K.;* Duh, C.-Y.*
(2011) "New cembranolides from the Dongsha atoll soft coral Lobophytum durum" Mar. Drugs 9, 1307-1318. (SCI) [國科會計畫編號:NSC99-2628-B-110-002-MY3]

 

25. Cheng, S.-Y.; Wang, C.-M.; Hsu, Y.-M.; Huang, T.-J.; Chou, S.-C.; Lin, E.-H.; Chou, C.-H.*
(2011) "Oleanane-type triterpenoids from the leaves and twigs of Fatsia polycarpa Hayata" J. Nat. Prod. 74, 1744-1750. (SCI) [國科會計畫編號:NSC-98-2321-B-039-001-MY3和NSC-98-2321-B-039-002-MY3]

 

26. Cheng, S.-Y.; Huang, K.-J.; Wang, S.-K.;* Duh, C.-Y.*

(2011) "Capilloquinol: A novel farnesyl quinol from the Dongsha atoll soft coral Sinularia capillosa" Mar. Drugs 9, 1469-1476. (SCI) [國科會計畫編號:NSC99-2628-B-110-002-MY3]

 

27. Cheng, S.-Y.; Wang, C.-M.; Cheng, H.-L.; Chen, H.-J.; Hsu, Y.-M.; Chou, C.-H.*

(2013) "Biological activity of oleanane triterpene derivatives obtained by chemical derivatization" Molecules 18, 13003-13019. (SCI) [國科會計畫編號:NSC102-2113-M-390-001]

 

28. Cheng, H.-L.; Nurkholis, N.; Cheng, S.-Y.; Huang, S.-D.; Lu, Y.-T.; Wang, X.-W.; Liu, Y.-L.; Chou. C.-H.*

(2013) "Anti-inflammatory effects and mechanisms of Fatsia polycarpa Hayata and its constituents" Evid.-based Complement Altern. 2013, Article ID 857213, 10 pages (SCI) [國科會計畫編號:NSC102-2113-M-390-001]

 

29. Cheng, S.-Y.; Shih, N.-L.; Chuang, C.-T.; Chiou, S.-F.; Yang, C.-N.; Wang, S.-K.; Duh, C.-Y.*

(2014) "Sinugyrosanolide A, an unprecedented C-4 norcembranoid, from the Formosan soft coral Sinularia gyrosa" Bioorg. Med. Chem. Lett. 24, 1562-1564. (SCI) [國科會計畫編號:NSC102-2113-M-390-001]

 

30. Cheng, S.-Y.; Shih, N.-L.; Hou, K.-Yu.; Ger, M.-J.; Yang, C.-N.; Wang, S.-K.; Duh, C.-Y.*

(2014) "Kelsoenethiol and dikelsoenyl ether, two unique kelsoane-type sesquiterpenes, from the Formosan soft coral Nephthea erecta" Bioorg. Med. Chem. Lett. 24, 473-475. (SCI) [國科會計畫編號:NSC102-2113-M-390-001]

 

31.Cheng, S.-Y.; Wang, S.-K.; Duh, C.-Y.*

(2014) "Secocrassumol, a seco-cembranoid from the Dongsha Atoll soft coral Lobophytum crassum" Mar. Drugs 12,6028-6037. (SCI) [MOST 102- 2113-M-390-001] [NSC 102- 2113-M-390-001]

 

32.Cheng, S.-Y.; Wang, S.-K.; Hsieh, M.-K.; Duh, C.-Y.*

(2015) "Polyoxygenated cembrane diterpenoids from the soft coral Sarcophyton ehrenbergi" Int. J. Mol. Sci. 16, 6140-6152. (SCI)

 

33.Lin, Y.-C.; Chang, J.-C.; Cheng, S.-Y.; Wang, C.-M.; Jhan, Y.-L.; Lo, I-W.; Hsu, Y.-M.; Liao, C.-C.; Hwang, C.-C.; Chou, C.-H.*

(2015) "New Bioactive Chromanes from Litchi chinensis" J. Agric. Food Chem. 63,2472-2478. (SCI)

 

34.Cheng, S.-Y; Wang, S.-K.; Chen, P.-W.; Duh, C.-Y.*

(2015) "Sandensone A, a novel sesquiterpenoid from the Formosan soft coral Sinularia sandensis" Bioorg. Med. Chem. Lett. 25,2353-2355.

 

35. Cheng, S.-Y; Wang, S.-K.; Ou, Y.-H.; Duh, C.-Y.*

(2016) "Mollisolactones A and B, novel dinormonoterpenes from the soft coral Sinularia mollis" Bioorg. Med. Chem. Lett. 26, 879–881

 

研討會論文:

1. Cheng, S.-Y.; Shen, Y.-C.*
(2004) “Chemical Transformation of Ambrein from Sperm Whale Physeter macrocephalus L.” 國立中山大學海洋生物科技暨資源學系哥倫布研究成果發表會,國立中山大學,高雄。(Poster) (碩一組第三名)

 

2. Cheng, S.-Y.; Shen, Y.-C.*
(2004) “Chemical Transformation and Biological Activities of Ambrein.” International Biotech Conference & Exhibition (IBC & E), Nov. 25-27, Kaohsiung, Taiwan. (Poster)

 

3. Cheng S.-Y.; Shen, Y.-C.*
(2005) “Studies on Chemical Transformation and Biological Activities of Ambrein from Sperm Whale Physeter macrocephalus L.”國立中山大學海洋生物科技暨資源學系哥倫布研究成果發表會,國立中山大學,高雄。(Poster)

 

4. Cheng S.-Y.

(2006) “New Bioactive Metabolites from the Formosan Soft Coral Nephthea erecta”國立中山大學生物及環境科學學生論文聯合發表會,國立中山大學,高雄。(Poster) (第三名)

 

5. Cheng, S.-Y.; Duh, C.-Y.*
(2006) “New Bioactive Secondary Metabolites from the Formosan Soft Coral Nephthea erecta” 國立中山大學海洋生物科技暨資源學系哥倫布研究成果發表會,國立中山大學,高雄。(Poster) (博士組第一名)

 

6. Cheng, S.-Y.; Duh, C.-Y.*
(2006) “New Bioactive Metabolites from the Formosan Soft Coral Nephthea erecta.” IUPAC International Conference on Biodiversity and Natural Products (ICOB-5 & ISCNP-25), July 23-28, 2006, Kyoto, Japan. (Poster)

 

7. Cheng, S.-Y.; Duh, C.-Y.*
(2007) “New Glycosplingolipids from the Soft Coral Sarcophyton ehrenbergi” 九十六年度台灣藥學會年會暨學術研討會,高雄醫學大學,高雄。(Poster)

 

8. Cheng, S.-Y.; Duh, C.-Y.*
(2007) “New Cembranoids from the Soft Coral Sarcophyton ehrenbergi and Lobophyton sp.” 國立中山大學海洋生物科技暨資源學系哥倫布研究成果發表會,國立中山大學,高雄。(Poster) (博士組第二名)

 

9. Cheng, S.-Y.; Duh, C.-Y.*
(2007) “New Cembranoids from the Soft Corals Sarcophyton ehrenbergi and Lobophyton sp.” 第二十二屆天然藥物研討會,高雄醫學大學,高雄。(Poster)

 

10. Cheng, S.-Y.; Wen, Z.-H.; Chiou, S.-F.; Hsu, C.-H.; Duh, C.-Y.*
(2008) “New Glycosplingolipids and Densely Oxygenated Cembranolides from the Soft Corals Sarcophyton ehrenbergi and Lobophytum durum” 國立中山大學海洋生物科技暨資源學系哥倫布研究成果發表會,國立中山大學,高雄。(Poster) (博士組第一名)

 

11. Cheng, S.-Y.; Wang, C.-M.; Hsu, Y.-M.; Huang, T.-J.; Chou, S.-C.; Lin, E.-H.; Chou, C.-H.*
(2011) “Oleanane-type Triterpenoids from the Leaves and Twigs of Fatsia polycarpa Hayata” 建國100年國際中醫藥學術研討會暨第26屆天然藥物研討會,中國醫藥大學,台中。(Poster)

 

12. Cheng, S.-Y.;* Wang, C.-M.; Chen, H.-J.; Cheng, H.-L.; Hsu, Y.-M.; Jhan, Y.-L.; Chou, C.-H.*
(2012) “Chemical Conversions and Biological Activities of Oleanane-Type Triterpenoids and Saponins from Fatsia polycarpa” 第27屆天然藥物研討會,高雄醫藥大學,高雄。(Poster)

 

13. Hsu, C.-M.; Cheng, S.-Y.; Chou, C.-H.; Cheng, H.-L.*
(2012) “Study on the Hypoglycemic and Anti-inflammatory Activities of Natural Products Isolated from Cucurbita moschata” 第七屆高雄國際儀器展,高雄市政府工商展覽中心,高雄。(Poster) (佳作)

 

14. Nurkholis; Cheng, S.-Y.; Chou, C.-H.; Cheng, H.-L.*
(2012) “Efficacy of Natural Products Derived from Fatsia polycarpa as Anti-inflammatory Agents” 第七屆高雄國際儀器展,高雄市政府工商展覽中心,高雄。(Poster)

 

15. Nurkholis; Cheng, S.-Y.; Chou, C.-H.; Cheng, H.-L.*
(2012) “Study on the Anti-inflammatory Activity of Bioactive Compounds Isolated from Fatsia polycarpa。Symposium on Natural Products Chemistry for Graduate Students” (台灣天然物化學研究生研討會),國立海洋生物博物館,屏東。(Oral)

 

16. Lu, Y.-T.; Cheng, S.-Y.; Chou, C.-H.; Cheng, H.-L.*
(2012) “探討台灣八角金盤天然物及其衍生物的抗發炎效果。” Symposium on Natural Products Chemistry for Graduate Students (台灣天然物化學研究生研討會),國立海洋生物博物館,屏東。(Poster)

 

17. Lu, Y.-T.; Cheng, S.-Y.; Chou, C.-H.; Cheng, H.-L.*
(2012) “Study on the Anti-inflammatory Effects of Structurally Modified Natural Products Isolated from Fatsia polycarpa” Symposium on Natural Products Chemistry for Graduate Students (台灣天然物化學研究生研討會),國立海洋生物博物館,屏東。(Poster)

 

18. Chen, J.-H.; Chang, C.-M.; Cheng, S.-Y.*: Novel Sesquiterpenoids and Steroids from the Formosan Soft Corals Nephthea erecta and Nephthea chabroli。29th Symposium on Natural Product,

2014,Kaohsiung Medical University,Kaohsiung。(Poster)

 

19. Cai, R.-X.; Wu, Z.T.; Li, J.-X.; Chen, Y.-T.; Cheng, S.-Y.*: New Amberin-Type Triterpenoids from Sperm Whale Physeter macrocephalus L.。8th Kaohsiung International Instruments Show (2015 KIIS),

2015,Kaohsiung Exhibition Center,Kaohsiung。(Poster)

 

20. Chao, W.-C.; Lin, Y.-M.; Lin, C.-Y.; Cheng, S.-Y.*: Anti-fatty Liver and Cytotoxicity Triterpenoids from Musa paradisiaca Flowers。8th Kaohsiung International Instruments Show (2015 KIIS),

2015,Kaohsiung Exhibition Center,Kaohsiung。(Poster)

 

21. Chen, J.-H.; Chang, C.-M.; Cheng, S.-Y.*: New Bioactive Metabolites from the Soft Coral Nephthea chabroli。Symposium on Application of Taiwan's Agricultural Biotechnology and Natural Resources,

2015,Huisun Forest,Nantou。(Poster)

 

22. Lin, Y.-M.; Lin, C.-Y.; Li, J.-X.; Chen, Y.-T.; Cheng, S.-Y.*: Cytotoxicity and DAAO Inhibitor of Sesquiterpene Lactones from the Root of Saussurea costus。Symposium on Application of Taiwan's Agricultural Biotechnology and Natural Resources,

2015,Huisun Forest,Nantou。(Poster)

 

23. Chen, J.-H.; Chang, C.-M.; Cai, R.-X.; Wu, Z.-T.; Li, J.-X.; Chen, Y.-T.; Cheng, S.-Y.*: New Amberin-Type Analogues and 19-Oxygenated Steroids from Sperm Whale Physeter macrocephalus and the Soft Coral Nephthea chabroli。30th Symposium on Natural Product,

2015,Taipei Medical University,Taipei。(Poster)

 

24. Lin, Y.-M.; Chao, W.-C.; Hsiao, Y.-C.; Lin, C.-Y.; Wang, Y.-T.; Cheng, S.-Y.*: Cytotoxicity and DAAO Inhibitor of Sesquiterpenoids and Triterpenoids from Musa sapientum, Saussurea costus and Inula japonica。30th Symposium on Natural Product,

2015,Taipei Medical University,Taipei。(Poster)